App Profile: Flockhart CYP450 Table

The Flockhart Table (TM) is a drug interaction reference tool focused on the human cytochrome P450 system.

This drug interaction app is designed as a teaching and reference tool for health care providers (e.g., physicians, pharmacists, nurses) and researchers interested in drug interactions mediated by the cytochrome P450 system.

Drug substrates are classified by cytochrome P450 isoform(s) based on published evidence that the specific isoform(s) contributes to the metabolism of the drug. It does not necessarily follow that the isoform is the principal metabolic pathway in vivo, or that alterations in the rate of the metabolic reaction catalyzed by that isoform will have large effects on the pharmacokinetics of the drug.

The Flockhart Table (TM) only catalogs drug-drug interactions that are mediated by CYPs. Drug-drug interactions caused via other enzymes (e.g., UGTs) are not included in this table. In addition, some of the drugs listed here could be substrates of uptake and efflux drug transporters. However, drug-drug interactions caused by inhibition or induction of drug transporters are not included in this table.

This app is dedicated to the memory of a pioneer in clinical pharmacology and pharmacogenetics and the creator of this site, Dr. David A. Flockhart, MD, Ph.D.

DISCLAIMER: All content and information available on this app are intended solely as a guide for general information and educational purposes and are not intended to be used for actual medical treatment, medical advice, or as a statement of the standards of care required in any particular situation because circumstances and the patient's physical conditions can vary widely from one instance to another. This app provides only general information and guidance regarding potential health care or medical advice. It is your sole responsibility to determine whether any health or medical services, procedures, treatment(s), and recommendation are appropriate for your individual circumstance or if any services, procedures, treatment(s), or recommendations have been reviewed or approved by the U.S. Food and Drug Administration. Only a physician, pharmacist, or other health care professional should advise a patient on health or medical matters and should do so using a medical history and other factors identified, discussed, and documented as part of the health professional/patient relationship. Indiana University and the authors disclaim any liability, loss, injury, or damage incurred as a consequence, directly or indirectly, or the use and application of any of the content or information included or referenced in this app.